Two Kinase Family Dramas

نویسندگان

  • Thomas A. Leonard
  • James H. Hurley
چکیده

In this issue, Lietha and colleagues (2007) report the structure of focal adhesion kinase (FAK) and reveal how FAK maintains an autoinhibited state. Together with the structure of another tyrosine kinase, ZAP-70 (Deindl et al., 2007), this work highlights the diversity of mechanisms that nature has evolved within the kinase superfamily to regulate their activity through autoinhibition.

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عنوان ژورنال:
  • Cell

دوره 129  شماره 

صفحات  -

تاریخ انتشار 2007